Ki Summary

Reaction Details

Report a problem with these data

Target

26S proteasome non-ATPase regulatory subunit 14

Ligand

BDBM88993

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay

IC50

1330±155 nM

Citation

PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

26S proteasome non-ATPase regulatory subunit 14

Name:

26S proteasome non-ATPase regulatory subunit 14

Synonyms:

26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein

Type:

Protein

Mol. Mass.:

34576.68

Organism:

Homo sapiens (Human)

Description:

O00487

Residue:

310

Sequence:

MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK

BDBM88993

n/a

Name

BDBM88993

Synonyms:

MLS001304035 | SMR000718768 | cid_23703286 | sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-5-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-5-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2Z)-2-(2-aminothiazol-5-yl)-2-methyloximino-acetyl]amino]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2Z)-2-(2-azanyl-1,3-thiazol-5-yl)-2-methoxyimino-ethanoyl]amino]-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Type

Small organic molecule

Emp. Form.

C13H12N5O5S2

Mol. Mass.

382.395

SMILES

CO\N=C(\C(=O)N[C@H]1[C@H]2SCC=C(N2C1=O)C([O-])=O)c1cnc(N)s1 |c:11|

Structure