| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
|---|
| Ligand | BDBM79278 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
|---|
| IC50 | 3310±254 nM |
|---|
| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 26S proteasome non-ATPase regulatory subunit 14 |
|---|
| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
|---|
| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 34576.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00487 |
|---|
| Residue: | 310 |
|---|
| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
|
|
|
|---|
| BDBM79278 |
|---|
| n/a |
|---|
| Name | BDBM79278 |
|---|
| Synonyms: | 2-(2,4-diketo-1,3-diazaspiro[4.4]nonan-3-yl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methyl-phenyl]acetamide | 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methylphenyl]acetamide | 2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.4]nonan-3-yl]-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methyl-phenyl]ethanamide | MLS002171413 | SMR001251708 | cid_16319329 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N4O6S |
|---|
| Mol. Mass. | 486.541 |
|---|
| SMILES | COc1ccc(NS(=O)(=O)c2ccc(C)c(NC(=O)CN3C(=O)NC4(CCCC4)C3=O)c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
