| Reaction Details |
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 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
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| Ligand | BDBM89034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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| IC50 | 5420±432 nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| 26S proteasome non-ATPase regulatory subunit 14 |
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| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
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| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
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| Type: | Protein |
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| Mol. Mass.: | 34576.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00487 |
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| Residue: | 310 |
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| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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| BDBM89034 |
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| n/a |
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| Name | BDBM89034 |
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| Synonyms: | (1,2-dimethyl-3-imidazo[1,2-a]pyridin-4-iumyl)-diphenyl-sulfanylidenephosphorane;methyl sulfate | (1,2-dimethylimidazo[1,2-a]pyridin-4-ium-3-yl)-diphenyl-sulfanylidene--phosphane;methyl sulfate | (1,2-dimethylimidazo[1,2-a]pyridin-4-ium-3-yl)-diphenyl-thioxo-phosphorane;methyl sulfate | CHEMBL1598051 | MLS002703110 | SMR001566915 | cid_56643192 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2PS |
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| Mol. Mass. | 363.435 |
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| SMILES | Cc1c([n+]2ccccc2n1C)P(=S)(c1ccccc1)c1ccccc1 |
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| Structure | 
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