| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Zinc finger protein GLI1 |
|---|
| Ligand | BDBM89452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay |
|---|
| IC50 | 735±n/a nM |
|---|
| Citation |  PubChem, PC Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Zinc finger protein GLI1 |
|---|
| Name: | Zinc finger protein GLI1 |
|---|
| Synonyms: | GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 118579.34 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | EBI_101259 |
|---|
| Residue: | 1111 |
|---|
| Sequence: | MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETS
SCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSP
GGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATC
QLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDC
RWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTG
EKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHS
NEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKRE
REGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDL
SSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVS
LDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARG
SGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFK
SLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLN
PYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPEN
WGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSE
GSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLV
CNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPA
SANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPE
VGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTP
SPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
|
|
|
|---|
| BDBM89452 |
|---|
| n/a |
|---|
| Name | BDBM89452 |
|---|
| Synonyms: | 3-(methylsulfamoyl)benzoic acid [2-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]-2-oxoethyl] ester | 3-(methylsulfamoyl)benzoic acid [2-[2,5-dimethyl-1-(tetrahydrofurfuryl)pyrrol-3-yl]-2-keto-ethyl] ester | MLS002162632 | SMR001245032 | [2-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]-2-oxidanylidene-ethyl] 3-(methylsulfamoyl)benzoate | [2-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]-2-oxoethyl] 3-(methylsulfamoyl)benzoate | cid_4314554 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N2O6S |
|---|
| Mol. Mass. | 434.506 |
|---|
| SMILES | CNS(=O)(=O)c1cccc(c1)C(=O)OCC(=O)c1cc(C)n(CC2CCCO2)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
