Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor-binding protein

Ligand

BDBM37671

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex

EC50

>53000±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor-binding protein

Name:

Corticotropin-releasing factor-binding protein

Synonyms:

CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36143.95

Organism:

Homo sapiens (Human)

Description:

P24387

Residue:

322

Sequence:

MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL

BDBM37671

n/a

Name

BDBM37671

Synonyms:

2-(3-bromanyl-5-methoxy-4-oxidanyl-phenyl)-3-(furan-2-ylcarbonyl)-1-(5-methyl-1,2-oxazol-3-yl)-4-oxidanyl-2H-pyrrol-5-one | 2-(3-bromo-4-hydroxy-5-methoxyphenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2H-pyrrol-5-one | 2-(3-bromo-4-hydroxy-5-methoxyphenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(5-methyl-3-isoxazolyl)-2H-pyrrol-5-one | 5-(3-bromo-4-hydroxy-5-methoxy-phenyl)-4-(2-furoyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-3-pyrrolin-2-one | MLS000082281 | SMR000047006 | cid_665729

Type

Small organic molecule

Emp. Form.

C20H15BrN2O7

Mol. Mass.

475.246

SMILES

COc1cc(cc(Br)c1O)C1C(C(=O)c2ccco2)C(=O)C(=O)N1c1cc(C)on1

Structure