Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor-binding protein

Ligand

BDBM89703

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex

EC50

>53000±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor-binding protein

Name:

Corticotropin-releasing factor-binding protein

Synonyms:

CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36143.95

Organism:

Homo sapiens (Human)

Description:

P24387

Residue:

322

Sequence:

MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL

BDBM89703

n/a

Name

BDBM89703

Synonyms:

4,5-dimethoxy-2-[(5-methyl-3-phenyl-isoxazole-4-carbonyl)amino]benzoic acid methyl ester | 4,5-dimethoxy-2-[[(5-methyl-3-phenyl-4-isoxazolyl)-oxomethyl]amino]benzoic acid methyl ester | MLS000051717 | SMR000080551 | cid_1246353 | methyl 4,5-dimethoxy-2-[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonylamino]benzoate | methyl 4,5-dimethoxy-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]benzoate | methyl 4,5-dimethoxy-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}benzoate

Type

Small organic molecule

Emp. Form.

C21H20N2O6

Mol. Mass.

396.3933

SMILES

COC(=O)c1cc(OC)c(OC)cc1NC(=O)c1c(C)onc1-c1ccccc1

Structure