Ki Summary

Reaction Details

Report a problem with these data

Target

DNA dC->dU-editing enzyme APOBEC-3G

Ligand

BDBM80510

Substrate/Competitor

n/a

Meas. Tech.

SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2

Temperature

298.15±n/a K

IC50

601±n/a nM

Comments

extracted

Citation

PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

DNA dC->dU-editing enzyme APOBEC-3G

Name:

DNA dC->dU-editing enzyme APOBEC-3G

Synonyms:

ABC3G_HUMAN | APOBEC3G

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46419.54

Organism:

Homo sapiens (Human)

Description:

gi_13399304

Residue:

384

Sequence:

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
YYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRG
FLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFIS
KNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQP
WDGLDEHSQDLSGRLRAILQNQEN

BDBM80510

n/a

Name

BDBM80510

Synonyms:

2-(3-methyl-1-pyridin-1-iumyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]acetamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]acetamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]ethanamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide;chloride | MLS000771355 | SMR000344445 | cid_16196233

Type

Small organic molecule

Emp. Form.

C19H21F3N3O2

Mol. Mass.

380.3836

SMILES

Cc1ccc[n+](CC(=O)Nc2cc(ccc2N2CCOCC2)C(F)(F)F)c1

Structure