| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM278863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IRAK4 Kinase Assay |
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| pH | 7.2±n/a |
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| IC50 | 16.0±n/a nM |
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| Comments | extracted |
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| Citation |  Lim, J; Altman, MD; Gibeau, CR Thienopyrazine inhibitors of IRAK4 activity US Patent US10040802 Publication Date 8/7/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM278863 |
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| n/a |
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| Name | BDBM278863 |
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| Synonyms: | 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl-5- (trifluoromethyl)-1H- pyrazol-4- yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate | US10040802, Example 42 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F6N7O3S |
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| Mol. Mass. | 554.489 |
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| SMILES | OC(=O)C(F)(F)F.C[N]1=C(C(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)=CN1)C(F)(F)F |r,c:32,t:7| |
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| Structure | 
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