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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM278871
Substrate/Competitorn/a
Meas. Tech.IRAK4 Kinase Assay
pH7.2±n/a
IC50 0.700±n/a nM
Commentsextracted
Citation Lim JAltman MDGibeau CR Thienopyrazine inhibitors of IRAK4 activity US Patent  US10040802 Publication Date 8/7/2018
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM278871
n/a
NameBDBM278871
Synonyms:2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-(difluoromethyl) thiophen-3-yl] thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate | US10040802, Example 50
TypeSmall organic molecule
Emp. Form.C20H20F5N5O3S2
Mol. Mass.537.527
SMILESOC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3cscc3C(F)F)c2n1 |r|
Structure
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