Reaction Details |
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Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
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Ligand | BDBM279065 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PDE1 Inhibition Assay |
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pH | 7.6±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 5.30±n/a nM |
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Comments | extracted |
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Citation | Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgård, M; Rasmussen, LK; Clementson, CM 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent US10034861 Publication Date 7/31/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
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Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
Synonyms: | 3',5'-cyclic-AMP phosphodiesterase | 3',5'-cyclic-GMP phosphodiesterase | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Cam-PDE 1C | Hcam3 | PDE1C | PDE1C_HUMAN | Phosphodiesterase 1 | Phosphodiesterase 1C | Phosphodiesterase, PDE1/PDE5 |
Type: | Enzyme |
Mol. Mass.: | 80778.58 |
Organism: | Homo sapiens (Human) |
Description: | Q14123 |
Residue: | 709 |
Sequence: | MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR
SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE
QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLR
HFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
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BDBM279065 |
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n/a |
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Name | BDBM279065 |
Synonyms: | 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine | US10034861, Example 96 | US10512632, Example 96 | US10766893, Example S96 | US10806718, Example 96 | US11026923, Example 96 | US11491140, Example 96 | US11634416, Example 96 |
Type | Small organic molecule |
Emp. Form. | C23H26N6O2 |
Mol. Mass. | 418.4915 |
SMILES | COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 |
Structure |
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