Reaction Details |
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Target | Phosphodiesterase |
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Ligand | BDBM14754 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay |
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pH | 7.5±0 |
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Temperature | 297.15±0 K |
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IC50 | 2.5e+4±n/a nM |
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Citation | Wang, H; Kunz, S; Chen, G; Seebeck, T; Wan, Y; Robinson, H; Martinelli, S; Ke, H Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. J Biol Chem287:11788-97 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Phosphodiesterase |
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Name: | Phosphodiesterase |
Synonyms: | Cyclic nucleotide specific phosphodiesterase | Phosphodiesterase (TcrPDEC) |
Type: | Protein |
Mol. Mass.: | 103074.59 |
Organism: | Trypanosoma cruzi |
Description: | Q53I59 |
Residue: | 924 |
Sequence: | MSEDAGLPVPRSQWVERGVSCATCGKRFSLFTAKSNCPCCGKLCCSDCVQAECAIVGGSA
PSKVCIDCFSMLQSRRRVEPDEGSSFREFNAASAFPLQTRLLADGRVESGETSRVSPPND
GRVQHVSRANGYSNSLPVLDEYVDDLLRKSELLRMENDVLLNRLREQEAEIHALRLERDR
AVARIVPDGGSMAGRSGLPQVSDEIVKELRGELAVAHLRIESVKRELKNALDRAKSSETM
VRNLKQGLCNYKEEVVRPLQSREEVEMLPGVNGRRDMISTRRLPPSIVQDTILAVVPPKS
CAAIGTDVDLRDWGFDTFEVASRVPSVLQSVAMHVALAWNFFASQEEAQKWAFLVAAVEN
NYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTNAF
LAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHLIGHT
DMSLHSETIAKHGAKLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARKWLVILQ
EFADQAEDERRRGLPVTPGFDTPSSVEKSQIPFLDFFVIPTFDLLHQLFPSIEEPLHNLR
KLRELYAAKAGVTTPFPPPVDYRSREERIRSLEAELAYFRRREEEFHRQLQELRTASENE
NKSSAAPMTREGALNKQSQLVCRGEGNMNADWADAGGGFRNGKDVRDLQDVSMDHLVSSK
TVESDTGDSGPRGRRGSKAETTKAYERKLGEREAALMATARLLENREKRLAVFSEKLAEI
AEGLHEERKRLQPMEEFKTPCFSRETELISEESASMDVTHRFSTQWEAEERLARKYRELD
ELLLIVRAMRMGYAARRNTNLGWKALSATLAEREAAISEAVELSRQRRRHLEEGRGPHPT
ATHLDRLENATFQLMSAITLLTQC
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BDBM14754 |
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n/a |
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Name | BDBM14754 |
Synonyms: | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline | 6,7-dimethoxy-1-veratryl-isoquinoline;hydrochloride | CHEMBL19224 | Papaverine |
Type | Small organic molecule |
Emp. Form. | C20H21NO4 |
Mol. Mass. | 339.385 |
SMILES | COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC |
Structure |
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