| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit A |
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| Ligand | BDBM50107009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 3.0e+4±n/a nM |
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| Citation |  Karkare, S; Chung, TT; Collin, F; Mitchenall, LA; McKay, AR; Greive, SJ; Meyer, JJ; Lall, N; Maxwell, A The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem288:5149-56 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit A |
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| Name: | DNA gyrase subunit A |
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| Synonyms: | GYRA_MYCTU | Type IIA topoisomerase subunit GyrA | gyrA |
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| Type: | Protein |
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| Mol. Mass.: | 92261.11 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | P9WG47 |
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| Residue: | 838 |
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| Sequence: | MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMF
DSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPG
NDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGG
IAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGT
ADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGIS
NIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQ
LIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAG
LIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVR
DELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRG
GKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLL
AFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELV
GAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREG
TYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSG
GGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
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| BDBM50107009 |
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| n/a |
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| Name | BDBM50107009 |
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| Synonyms: | 5-Hydroxy-7-methyl-[1,4]naphthoquinone | 5-hydroxy-7-methyl-1,4-naphthoquinone | 7-methyljuglone | CHEMBL430853 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H8O3 |
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| Mol. Mass. | 188.1794 |
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| SMILES | Cc1cc(O)c2C(=O)C=CC(=O)c2c1 |c:8| |
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| Structure | 
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