Reaction Details |
| Report a problem with these data |
Target | DNA ligase A |
---|
Ligand | BDBM93107 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Assay |
---|
IC50 | 4.60e+4± 2.5e+3 nM |
---|
Citation | Dube, C; Kukshal, V; Srivastava, SK; Tripathi, RP; Ramachandran, R NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design Medicinal Chemistry Research17:189-198 (2008) |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA ligase A |
---|
Name: | DNA ligase A |
Synonyms: | DNA Ligase (MtuLigA) | DNLJ_MYCTU | NAD-dependent DNA ligase | Polydeoxyribonucleotide synthase [NAD(+)] | Polydeoxyribonucleotide synthase [NAD+] | lig | ligA |
Type: | Enzyme |
Mol. Mass.: | 75276.13 |
Organism: | Mycobacterium tuberculosis |
Description: | The C-terminally His-tagged full-length MtuLigA protein was cloned and expressed in E. coli. |
Residue: | 691 |
Sequence: | MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPE
LRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIHAEVGDAAHYLC
ELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGDDYPVPEVLE
VRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGH
VEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVK
VDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRITPFAFMTPVKVAG
STVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVELRDGSEREFIMPTTCPE
CGSPLAPEKEGDADIRCPNARGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIA
DEGELFALTERDLLRTDLFRTKAGELSANGKRLLVNLDKAKAAPLWRVLVALSIRHVGPT
AARALATEFGSLDAIAAASTDQLAAVEGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRM
VDERDESVPRTLAGLTIVVTGSLTGFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPG
SKYDKAVELGVPILDEDGFRRLLADGPASRT
|
|
|
BDBM93107 |
---|
n/a |
---|
Name | BDBM93107 |
Synonyms: | Arylamino compound, 1 |
Type | Small molecule |
Emp. Form. | C18H28ClN3 |
Mol. Mass. | 321.888 |
SMILES | CCN(CC)CCCC(C)Nc1ccnc2CC(Cl)C=Cc12 |c:19| |
Structure |
|