Reaction Details |
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Target | DNA ligase A |
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Ligand | BDBM22986 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | 1.35e+4± 6e+2 nM |
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Citation | Dube, C; Kukshal, V; Srivastava, SK; Tripathi, RP; Ramachandran, R NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design Medicinal Chemistry Research17:189-198 (2008) |
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More Info.: | Get all data from this article, Assay Method |
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DNA ligase A |
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Name: | DNA ligase A |
Synonyms: | DNA Ligase (MtuLigA) | DNLJ_MYCTU | NAD-dependent DNA ligase | Polydeoxyribonucleotide synthase [NAD(+)] | Polydeoxyribonucleotide synthase [NAD+] | lig | ligA |
Type: | Enzyme |
Mol. Mass.: | 75276.13 |
Organism: | Mycobacterium tuberculosis |
Description: | The C-terminally His-tagged full-length MtuLigA protein was cloned and expressed in E. coli. |
Residue: | 691 |
Sequence: | MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPE
LRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIHAEVGDAAHYLC
ELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGDDYPVPEVLE
VRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGH
VEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVK
VDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRITPFAFMTPVKVAG
STVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVELRDGSEREFIMPTTCPE
CGSPLAPEKEGDADIRCPNARGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIA
DEGELFALTERDLLRTDLFRTKAGELSANGKRLLVNLDKAKAAPLWRVLVALSIRHVGPT
AARALATEFGSLDAIAAASTDQLAAVEGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRM
VDERDESVPRTLAGLTIVVTGSLTGFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPG
SKYDKAVELGVPILDEDGFRRLLADGPASRT
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BDBM22986 |
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n/a |
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Name | BDBM22986 |
Synonyms: | 18-[6-(piperidin-1-yl)hexyl]-8-thia-18-azatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2(7),3,5,12(17),13,15-heptaene | N-substituted tetracyclic indole | Tetracyclic indole derivative, 5 |
Type | Small organic molecule |
Emp. Form. | C27H34N2S |
Mol. Mass. | 418.637 |
SMILES | C(CCCn1c-2c(CCSc3ccccc-23)c2ccccc12)CCN1CCCCC1 |
Structure |
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