Ki Summary

Reaction Details

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Target

Protein Wnt-3a

Ligand

BDBM37170

Substrate/Competitor

n/a

IC50

1890±n/a nM

Citation

PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay(2012)[AID]

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Protein Wnt-3a

Name:

Protein Wnt-3a

Synonyms:

WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor

Type:

PROTEIN

Mol. Mass.:

39269.29

Organism:

Mus musculus

Description:

ChEMBL_813156

Residue:

352

Sequence:

MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK

BDBM37170

n/a

Name

BDBM37170

Synonyms:

3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-1,5,6,7-tetrahydroindole-2-carboxylic acid prop-2-enyl ester | 4-keto-3-methyl-6-(3,4,5-trimethoxyphenyl)-1,5,6,7-tetrahydroindole-2-carboxylic acid allyl ester | MLS000116495 | SMR000093465 | cid_5308217 | prop-2-enyl 3-methyl-4-oxidanylidene-6-(3,4,5-trimethoxyphenyl)-1,5,6,7-tetrahydroindole-2-carboxylate | prop-2-enyl 3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-1,5,6,7-tetrahydroindole-2-carboxylate

Type

Small organic molecule

Emp. Form.

C22H25NO6

Mol. Mass.

399.437

SMILES

COc1cc(cc(OC)c1OC)C1Cc2[nH]c(C(=O)OCC=C)c(C)c2C(=O)C1

Structure