| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial PAS domain-containing protein 1 |
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| Ligand | BDBM94008 |
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| Substrate/Competitor | n/a |
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| IC50 | 1050±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Endothelial PAS domain-containing protein 1 |
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| Name: | Endothelial PAS domain-containing protein 1 |
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| Synonyms: | BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96453.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1506501 |
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| Residue: | 870 |
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| Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
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| BDBM94008 |
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| n/a |
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| Name | BDBM94008 |
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| Synonyms: | 3-[(4-methyl-5,6,7,8-tetrahydroquinazolin-2-yl)sulfanylmethyl]benzoic acid | 3-[[(4-methyl-5,6,7,8-tetrahydroquinazolin-2-yl)thio]methyl]benzoic acid | MLS000715774 | SMR000277291 | cid_971004 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2O2S |
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| Mol. Mass. | 314.402 |
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| SMILES | Cc1nc(SCc2cccc(c2)C(O)=O)nc2CCCCc12 |
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| Structure | 
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