| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelial PAS domain-containing protein 1 |
|---|
| Ligand | BDBM94054 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 1410±n/a nM |
|---|
| Citation |  PubChem, PC Dose response confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay PubChem Bioassay(2012)[AID] |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Endothelial PAS domain-containing protein 1 |
|---|
| Name: | Endothelial PAS domain-containing protein 1 |
|---|
| Synonyms: | BHLHE73 | EPAS1 | EPAS1_HUMAN | HIF2A | MOP2 | PASD2 | endothelial PAS domain-containing protein 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 96453.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1506501 |
|---|
| Residue: | 870 |
|---|
| Sequence: | MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF
QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ
DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL
PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
RYDCEVNVPVLGSSTLLQGGDLLRALDQAT
|
|
|
|---|
| BDBM94054 |
|---|
| n/a |
|---|
| Name | BDBM94054 |
|---|
| Synonyms: | 1-[3-(2-keto-4-methyl-6,7,8,9-tetrahydrobenzofuro[3,2-g]chromen-3-yl)propanoyl]-4-phenyl-isonipecotic acid | 1-[3-(4-methyl-2-oxidanylidene-6,7,8,9-tetrahydro-[1]benzofuro[3,2-g]chromen-3-yl)propanoyl]-4-phenyl-piperidine-4-carboxylic acid | 1-[3-(4-methyl-2-oxo-6,7,8,9-tetrahydro-[1]benzofuro[3,2-g]chromen-3-yl)propanoyl]-4-phenylpiperidine-4-carboxylic acid | 1-[3-(4-methyl-2-oxo-6,7,8,9-tetrahydrobenzofuro[3,2-g][1]benzopyran-3-yl)-1-oxopropyl]-4-phenyl-4-piperidinecarboxylic acid | MLS001140907 | SMR000650163 | cid_1759638 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H31NO6 |
|---|
| Mol. Mass. | 513.5809 |
|---|
| SMILES | Cc1c(CCC(=O)N2CCC(CC2)(C(O)=O)c2ccccc2)c(=O)oc2cc3oc4CCCCc4c3cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
