Reaction Details |
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Target | Corticotropin-releasing factor-binding protein |
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Ligand | BDBM83003 |
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Substrate/Competitor | n/a |
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IC50 | 4480±n/a nM |
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Citation | PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article |
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Corticotropin-releasing factor-binding protein |
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Name: | Corticotropin-releasing factor-binding protein |
Synonyms: | CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 36143.95 |
Organism: | Homo sapiens (Human) |
Description: | P24387 |
Residue: | 322 |
Sequence: | MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL
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BDBM83003 |
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n/a |
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Name | BDBM83003 |
Synonyms: | (6E)-5-azanylidene-6-[[3-methoxy-4-[2-(4-methylphenoxy)ethoxy]phenyl]methylidene]-2-methylsulfonyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-5-imino-2-mesyl-6-[3-methoxy-4-[2-(4-methylphenoxy)ethoxy]benzylidene]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-5-imino-6-[[3-methoxy-4-[2-(4-methylphenoxy)ethoxy]phenyl]methylidene]-2-methylsulfonyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-5-imino-6-{3-methoxy-4-[2-(4-methylphenoxy)ethoxy]benzylidene}-2-(methylsulfonyl)-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | MLS001199626 | SMR000560211 | cid_24792310 |
Type | Small organic molecule |
Emp. Form. | C23H22N4O6S2 |
Mol. Mass. | 514.574 |
SMILES | COc1cc(C=C2C(=O)N=C3SC(=NN3C2=N)S(C)(=O)=O)ccc1OCCOc1ccc(C)cc1 |w:5.4,c:12,t:9| |
Structure |
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