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TargetTyrosine-protein kinase transforming protein Src
LigandBDBM4030
Substrate/Competitorpoly(E,Y)
Meas. Tech.Kinase Inhibition Assay
IC50 7200±n/a nM
Citation Rewcastle, GW; Palmer, BD; Dobrusin, EM; Fry, DW; Kraker, AJ; Denny, WA Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide). J Med Chem37:2033-42 (1994) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosine-protein kinase transforming protein Src
Name:Tyrosine-protein kinase transforming protein Src
Synonyms:P60-Src | SRC_AVISR | V-SRC | pp60v-src
Type:Enzyme
Mol. Mass.:58884.32
Organism:Avian sarcoma virus
Description:P00525
Residue:526
Sequence:
MGSSKSKPKDPSQRRCSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYR
MPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
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  Blast E-value cutoff:
BDBM4030
poly(E,Y)
Name:poly(E,Y)
Synonyms:n/a
Type:Random Polymer
Mol. Mass.:358.43
Organism:n/a
Description:poly[(glu)4(tyr)l]. 5 uM ATP containing 0.2 uCi 32P labeled ATP as co-substrate.
Residue:3
Sequence:
n/a