| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte nuclear factor 4-alpha |
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| Ligand | BDBM40594 |
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| Substrate/Competitor | n/a |
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| IC50 | 1600±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Hepatocyte nuclear factor 4-alpha |
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| Name: | Hepatocyte nuclear factor 4-alpha |
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| Synonyms: | HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52790.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_606516 |
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| Residue: | 474 |
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| Sequence: | MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC
FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK
IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK
DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK
GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL
FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW
PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
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| BDBM40594 |
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| n/a |
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| Name | BDBM40594 |
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| Synonyms: | 2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-N-(4-methylphenyl)acetamide | 2-[[5,6-bis(2-furyl)-1,2,4-triazin-3-yl]thio]-N-(p-tolyl)acetamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-(4-methylphenyl)acetamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-(4-methylphenyl)ethanamide | MLS000077593 | SMR000042109 | cid_6400935 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N4O3S |
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| Mol. Mass. | 392.431 |
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| SMILES | Cc1ccc(NC(=O)CSc2nnc(-c3ccco3)c(n2)-c2ccco2)cc1 |
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| Structure | 
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