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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neutrophil elastase | ||
| Ligand | BDBM405536 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Inhibition Assay | ||
| IC50 | <1.000±n/a nM | ||
| Citation |  Gnamm, C; Oost, T; Peters, S; Rudolf, K Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent US Patent | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neutrophil elastase | |||
| Name: | Neutrophil elastase | ||
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 28532.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08246 | ||
| Residue: | 267 | ||
| Sequence: |
| ||
| BDBM405536 | |||
| n/a | |||
| Name | BDBM405536 | ||
| Synonyms: | USRE47493, Example 75.9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H27F3N4O5S | ||
| Mol. Mass. | 600.609 | ||
| SMILES | CS(O)(O)c1cc(ccc1[C@H]1N(C(=O)NC2C3CC2C3)C(=O)N(C2=C1C(=O)CCC2)c1cccc(c1)C(F)(F)F)C#N |r,wU:10.10,c:26,(4,4.09,;2.67,3.32,;1.9,1.98,;3.44,1.98,;1.33,4.09,;1.33,5.63,;,6.4,;-1.33,5.63,;-1.33,4.09,;,3.32,;,-.44,;1.33,-1.21,;2.67,-.44,;2.67,1.1,;4,-1.21,;5.41,-.59,;6.18,.75,;7.51,-.02,;6.74,-1.36,;6.8,-.17,;1.33,-2.75,;2.67,-3.52,;,-3.52,;-1.33,-2.75,;-1.33,-1.21,;-2.67,-.44,;-2.67,1.1,;-4,-1.21,;-4,-2.75,;-2.67,-3.52,;,-5.06,;-1.33,-5.83,;-1.33,-7.37,;,-8.14,;1.38,-7.4,;1.33,-5.83,;2.72,-8.17,;4.05,-8.94,;1.95,-9.5,;3.49,-6.84,;,7.94,;,9.48,)| | ||
| Structure | 
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