| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine--tRNA ligase |
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| Ligand | BDBM71661 |
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| Substrate/Competitor | n/a |
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| IC50 | 2048±n/a nM |
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| Citation |  PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article |
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| Methionine--tRNA ligase |
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| Name: | Methionine--tRNA ligase |
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| Synonyms: | methionyl-tRNA synthetase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86905.45 |
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| Organism: | Trypanosoma brucei brucei strain 927/4 GUTat10.1 |
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| Description: | gi_71746704 |
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| Residue: | 773 |
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| Sequence: | MALKLLSEKANSQALKVLLCSYYVKRPVEVSLSGAYATPILHHPAFKQPIIAPNEMARVI
LFYSVEPTSNNGGAADSSNGDGTASPVAGLTNLTLEHETWLEWEATTFTRAVHPLYTQRR
QTAESLAVFSYLDKKISENDDRCVYSPAVEGKGAADPTDAVSTFFIDCIVWCAVLPALCE
SGVLRDSEKQQLPHLVKWFNTFQKEQKTLIDNAFENLSVQEAADFLRCPRVYKVSAKVEK
VFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQK
QVSPYDFTAAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYE
GWYSISDESFLTPQNITDGVDKDGNPCKVSLESGHVVTWVSEENYMFRLSAFRERLLEWY
HANPGCIVPEFRRREVIRAVEKGLPDLSVSRKKETLHNWAIPVPGNPDHCVYVWLDALTN
YLTGSRLRVDESGKEVSLADDFSELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPK
KIVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIA
RLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPD
IQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRK
SVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRSTENTKST
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| BDBM71661 |
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| n/a |
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| Name | BDBM71661 |
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| Synonyms: | 3-[2-(2-Methylcarbamoylmethyl-benzoimidazol-1-yl)-acetylamino]-benzoic acid ethyl ester | 3-[[2-[2-[2-(methylamino)-2-oxoethyl]-1-benzimidazolyl]-1-oxoethyl]amino]benzoic acid ethyl ester | 3-[[2-[2-[2-keto-2-(methylamino)ethyl]benzimidazol-1-yl]acetyl]amino]benzoic acid ethyl ester | MLS000073857 | SMR000002627 | cid_656250 | ethyl 3-[2-[2-[2-(methylamino)-2-oxidanylidene-ethyl]benzimidazol-1-yl]ethanoylamino]benzoate | ethyl 3-[[2-[2-[2-(methylamino)-2-oxoethyl]benzimidazol-1-yl]acetyl]amino]benzoate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O4 |
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| Mol. Mass. | 394.4238 |
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| SMILES | CCOC(=O)c1cccc(NC(=O)Cn2c(CC(=O)NC)nc3ccccc23)c1 |
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| Structure | 
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