| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Methionine--tRNA ligase |
|---|
| Ligand | BDBM74708 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 401.41±n/a nM |
|---|
| Citation |  PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) PubChem Bioassay(2013)[AID] |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| Methionine--tRNA ligase |
|---|
| Name: | Methionine--tRNA ligase |
|---|
| Synonyms: | methionyl-tRNA synthetase |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 86905.45 |
|---|
| Organism: | Trypanosoma brucei brucei strain 927/4 GUTat10.1 |
|---|
| Description: | gi_71746704 |
|---|
| Residue: | 773 |
|---|
| Sequence: | MALKLLSEKANSQALKVLLCSYYVKRPVEVSLSGAYATPILHHPAFKQPIIAPNEMARVI
LFYSVEPTSNNGGAADSSNGDGTASPVAGLTNLTLEHETWLEWEATTFTRAVHPLYTQRR
QTAESLAVFSYLDKKISENDDRCVYSPAVEGKGAADPTDAVSTFFIDCIVWCAVLPALCE
SGVLRDSEKQQLPHLVKWFNTFQKEQKTLIDNAFENLSVQEAADFLRCPRVYKVSAKVEK
VFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVFALTGTDEHGQKVAEAAKQK
QVSPYDFTAAVAGEFKKCFEQMDYSIDYFIRTTNEQHKAVVKELWTKLEQKGDIYLGRYE
GWYSISDESFLTPQNITDGVDKDGNPCKVSLESGHVVTWVSEENYMFRLSAFRERLLEWY
HANPGCIVPEFRRREVIRAVEKGLPDLSVSRKKETLHNWAIPVPGNPDHCVYVWLDALTN
YLTGSRLRVDESGKEVSLADDFSELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPK
KIVAHGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYSDKNMIA
RLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQLIKDLPGTADHYYLIPD
IQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPERLRTVLYITLEGVRVTTLLLSPILPRK
SVVIFDMLGVPEVHRKGIENFEFGAVPPGTRLGPAVEGEVLFSKRSTENTKST
|
|
|
|---|
| BDBM74708 |
|---|
| n/a |
|---|
| Name | BDBM74708 |
|---|
| Synonyms: | 2-(1H-benzimidazol-2-ylmethylsulfanyl)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole | 2-(1H-benzimidazol-2-ylmethylthio)-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole | 2-[5-(2,4-Dichloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-1H-benzoimidazole | MLS000528062 | SMR000120636 | cid_1116759 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H10Cl2N4OS |
|---|
| Mol. Mass. | 377.248 |
|---|
| SMILES | Clc1ccc(-c2nnc(SCc3nc4ccccc4[nH]3)o2)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
