| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin receptor type 2 |
|---|
| Ligand | BDBM97397 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FLIPR Ca2+ Flux Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 17±0 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Kuduk, SD; Skudlarek, JW 2-pyridyloxy-4-nitrile orexin receptor antagonists US Patent US20130102619 Publication Date 4/25/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin receptor type 2 |
|---|
| Name: | Orexin receptor type 2 |
|---|
| Synonyms: | Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 52508.46 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P56719 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVS
CIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARR
KTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLS
EHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
|
|
|
|---|
| BDBM97397 |
|---|
| n/a |
|---|
| Name | BDBM97397 |
|---|
| Synonyms: | Orexin receptor antagonist 29 | Orexin receptor antagonist 7 | Orexin receptor antagonist, 7 | US20130102619, 29 |
|---|
| Type | Small molecule |
|---|
| Emp. Form. | C21H19ClN6O2 |
|---|
| Mol. Mass. | 422.868 |
|---|
| SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccc(Cl)cc1-n1nccn1)Oc1cc(ccn1)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
