| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Ligand | BDBM279841 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical JAK Kinase Assay |
|---|
| pH | 7.5±n/a |
|---|
| Ki | 5.5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hudson, R; Kozak, J; Fleury, M; Fatheree, PR; Beausoleil, A; Podesto, DD Pyrimidine compounds as JAK kinase inhibitors US Patent US10028960 Publication Date 7/24/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Name: | Non-receptor tyrosine-protein kinase TYK2 |
|---|
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 133666.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29597 |
|---|
| Residue: | 1187 |
|---|
| Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
|
|
|
|---|
| BDBM279841 |
|---|
| n/a |
|---|
| Name | BDBM279841 |
|---|
| Synonyms: | US10028960, Example 2-5 | US10485803, Example 2-5 | US11110095, Example 2-5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H30N8O2 |
|---|
| Mol. Mass. | 426.5153 |
|---|
| SMILES | COc1cc(Nc2cc(CO)[nH]n2)nc(n1)N(C)[C@H]1C[C@@H]2CCC[C@H](C1)N2CCC#N |r,TLB:27:26:23.22.21:18.25.19| |
|---|
| Structure | 
|
|---|
Search and Browse
