| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B [2-344]/Inner centromere protein [826-918] |
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| Ligand | BDBM50419247 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Aurora B Enzyme Assay |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 2.0e+4±n/a nM |
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| Comments | extracted |
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| Citation |  Atkinson, FL; Patel, VK Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase US Patent US8470835 Publication Date 6/25/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B [2-344]/Inner centromere protein [826-918] |
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| Name: | Aurora kinase B [2-344]/Inner centromere protein [826-918] |
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| Synonyms: | Aurora B/INCENP |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 0 components. |
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| Component 1 |
| Name: | Aurora kinase B [2-344] |
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| Synonyms: | AIK2 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Recombinant human Aurora B (aa 2-344) | STK1 | STK12 | STK5 |
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| Type: | Protein |
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| Mol. Mass.: | 39196.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 343 |
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| Sequence: | AQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENS
SGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQ
LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIM
EELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLP
PEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQ
DLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| Component 2 |
| Name: | Inner centromere protein [826-918] |
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| Synonyms: | INCENP | INCE_HUMAN | Inner centromere protein (INCENP) |
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| Type: | Protein |
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| Mol. Mass.: | 10562.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NQS7[826-918] |
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| Residue: | 93 |
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| Sequence: | LNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSK
PRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH
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| BDBM50419247 |
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| n/a |
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| Name | BDBM50419247 |
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| Synonyms: | CHEMBL1835071 | US8470835, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N6O2 |
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| Mol. Mass. | 342.3956 |
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| SMILES | Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1 |r| |
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| Structure | 
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