Reaction Details |
| Report a problem with these data |
Target | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
---|
Ligand | BDBM280030 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Assays for IDH2m R140Q Inhibitors |
---|
pH | 7.5±n/a |
---|
Temperature | 298.15±n/a K |
---|
IC50 | <50±n/a nM |
---|
Comments | extracted |
---|
Citation | Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D Therapeutically active compounds and their methods of use US Patent US10028961 Publication Date 7/24/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
---|
Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
Synonyms: | IDH2 | IDH2(R140Q) | IDHP_HUMAN | idh2 r140q |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50823.17 |
Organism: | Homo sapiens (Human) |
Description: | P48735 (R140Q) |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
|
|
|
BDBM280030 |
---|
n/a |
---|
Name | BDBM280030 |
Synonyms: | US10028961, Compound 183 | US10172864, Compound 183 | US10946023, Compound 183 |
Type | Small organic molecule |
Emp. Form. | C19H21F7N6S |
Mol. Mass. | 498.464 |
SMILES | FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1 |
Structure |
|