| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Ligand | BDBM280249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assays for IDH2m R140Q Inhibitors |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <50±n/a nM |
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| Comments | extracted |
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| Citation |  Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D Therapeutically active compounds and their methods of use US Patent US10028961 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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| Synonyms: | IDH2 | IDH2(R140Q) | IDHP_HUMAN | idh2 r140q |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50823.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48735 (R140Q) |
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| Residue: | 452 |
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| Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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| BDBM280249 |
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| n/a |
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| Name | BDBM280249 |
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| Synonyms: | US10028961, Compound 408 | US10172864, Compound 408 | US10946023, Compound 408 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F6N7 |
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| Mol. Mass. | 447.3808 |
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| SMILES | FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1 |
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| Structure | 
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