| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 1 |
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| Ligand | BDBM98557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ECL Assay |
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| pH | 6.5±0 |
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| IC50 | 5e+3±n/a nM |
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| Citation |  Hills, ID; Coburn, CA; Graham, SL; Moore, KP; Nantermet, PG; Rajapakse, HA; Stachel, SJ; Zhu, H 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease US Patent US8492387 Publication Date 7/23/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Beta-secretase 1 |
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| Name: | Beta-secretase 1 |
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| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
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| Type: | Protein |
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| Mol. Mass.: | 55755.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56817 |
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| Residue: | 501 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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| BDBM98557 |
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| n/a |
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| Name | BDBM98557 |
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| Synonyms: | US8492387, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24F3N3O2 |
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| Mol. Mass. | 467.4829 |
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| SMILES | COc1ccc(cc1)C(Cc1ccc(cc1)C(F)(F)F)c1[nH]c(N)nc1C(O)c1ccccc1 |
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| Structure | 
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