Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM98555 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ECL Assay |
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pH | 6.5±0 |
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IC50 | 3.3e+3±n/a nM |
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Citation | Hills, ID; Coburn, CA; Graham, SL; Moore, KP; Nantermet, PG; Rajapakse, HA; Stachel, SJ; Zhu, H 2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease US Patent US8492387 Publication Date 7/23/2013 |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM98555 |
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n/a |
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Name | BDBM98555 |
Synonyms: | US8492387, 126 |
Type | Small organic molecule |
Emp. Form. | C23H25F3N4O2 |
Mol. Mass. | 446.4654 |
SMILES | COc1ccc2c(CCC2(Cc2ccc(nc2)C(F)(F)F)c2cn(CCCO)c(N)n2)c1 |
Structure |
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