Reaction Details |
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Target | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
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Ligand | BDBM108763 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ITK Target Modulation PLC-gamma Assay |
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Temperature | 310.15±n/a K |
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IC50 | <1000±n/a nM |
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Comments | extracted |
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Citation | Jacobsen, EJ; Blinn, JR; Springer, JR; Hockerman, SL Heterocyclic ITK inhibitors for treating inflammation and cancer US Patent US9695200 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
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Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
Synonyms: | PLC1 | PLCG1 | PLCG1_HUMAN | Phospholipase C-gamma-1 |
Type: | PROTEIN |
Mol. Mass.: | 148518.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435182 |
Residue: | 1290 |
Sequence: | MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
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BDBM108763 |
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n/a |
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Name | BDBM108763 |
Synonyms: | US9695200, 91 |
Type | Small organic molecule |
Emp. Form. | C21H18N6O |
Mol. Mass. | 370.4072 |
SMILES | CNc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 |
Structure |
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