Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM280446 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro M4 &M2 Functional Assay |
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EC50 | 22.0±n/a nM |
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Citation | Livermore, D; White, K; Congreve, M; Brown, G; O Brien, M Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists US Patent US10030012 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM280446 |
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n/a |
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Name | BDBM280446 |
Synonyms: | US10030012, Example 76 | ethyl 4-{4-[2- (1,3-thiazol-4- ylmethoxy) pyridin- 3-yl]piperidin-1- yl}azepane-1- carboxylate |
Type | Small organic molecule |
Emp. Form. | C23H32N4O3S |
Mol. Mass. | 444.59 |
SMILES | CCOC(=O)N1CCCC(CC1)N1CCC(CC1)c1cccnc1OCc1cscn1 |
Structure |
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