| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM242748 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Competitive Binding Assays NK-3 receptor |
|---|
| pH | 7.4±n/a |
|---|
| Ki | 59.0±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hoveyda, H; Dutheuil, G; Fraser, G Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent US10030025 Publication Date 7/24/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52221.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29371 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
|
|
|
|---|
| BDBM242748 |
|---|
| n/a |
|---|
| Name | BDBM242748 |
|---|
| Synonyms: | US10030025, Compound 12 | US10836768, Cpd no 12 | US11731974, Compound 12 | US9422299, 12 | US9987274, Compound 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17FN6O2S |
|---|
| Mol. Mass. | 388.419 |
|---|
| SMILES | Cc1nsc(n1)-c1nnc2C(CCO)N(CCn12)C(=O)c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
