| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM242740 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Selectivity Assay with Human NK-1 |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 10300±n/a nM |
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| Comments | extracted |
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| Citation |  Hoveyda, H; Dutheuil, G; Fraser, G Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent US10030025 Publication Date 7/24/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM242740 |
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| n/a |
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| Name | BDBM242740 |
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| Synonyms: | US10030025, Compound 1 | US10836768, Cpd no 1 | US11731974, Compound 1 | US9422299, 1 | US9987274, Compound 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14Cl2N6OS |
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| Mol. Mass. | 409.293 |
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| SMILES | C[C@H]1N(CCn2c1nnc2-c1nc(C)ns1)C(=O)c1ccc(Cl)c(Cl)c1 |r| |
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| Structure | 
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