Reaction Details |
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Target | Guanylate cyclase soluble subunit alpha-1 |
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Ligand | BDBM280796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | sGC Binding Assay |
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pH | 7.4±n/a |
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Ki | 0.075±n/a nM |
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Comments | extracted |
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Citation | Berger, R; Chen, Y; Li, G; Garfunkle, J; Li, H; Miao, S; Raghavan, S; Smith, CJ; Stelmach, J; Whitehead, A; Zhang, R; Zhang, Y; Fu, J; Ji, G; Jiang, F Soluble guanylate cyclase stimulators US Patent US10030027 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Guanylate cyclase soluble subunit alpha-1 |
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Name: | Guanylate cyclase soluble subunit alpha-1 |
Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
Type: | Enzyme |
Mol. Mass.: | 77457.21 |
Organism: | Homo sapiens (Human) |
Description: | Q02108 |
Residue: | 690 |
Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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BDBM280796 |
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n/a |
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Name | BDBM280796 |
Synonyms: | (S)-3-(4-{4-amino-2-[6- chloro-1-(2,6- difluorobenzyl)-1H-indazol- 3-yl]-5-methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5- yl}phenyl)propanoic acid | US10030027, Example 64B | US10428076, Example 64B |
Type | Small organic molecule |
Emp. Form. | C30H23ClF2N6O3 |
Mol. Mass. | 588.992 |
SMILES | C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)cccc2F)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1 |r| |
Structure |
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