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TargetGuanylate cyclase soluble subunit alpha-1
LigandBDBM280851
Substrate/Competitorn/a
Meas. Tech.sGC Binding Assay
pH7.4±n/a
Ki 0.074±n/a nM
Commentsextracted
Citation Berger RChen YLi GGarfunkle JLi HMiao SRaghavan SSmith CJStelmach JWhitehead AZhang RZhang YFu JJi GJiang F Soluble guanylate cyclase stimulators US Patent  US10030027 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
Guanylate cyclase soluble subunit alpha-1
Name:Guanylate cyclase soluble subunit alpha-1
Synonyms:GCS-alpha-1 | GCS-alpha-3 | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:Enzyme
Mol. Mass.:77457.21
Organism:Homo sapiens (Human)
Description:Q02108
Residue:690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM280851
n/a
NameBDBM280851
Synonyms:3-{2-[4-amino-2-{6- chloro-1-[4- methylcyclohexylmethyl]- 1H-indazol-3-yl}-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl]-1,3- oxazol-4-yl}-2,2- dimethylpropanoic acid | US10030027, Example 132AA | US10030027, Example 132AB
TypeSmall organic molecule
Emp. Form.C30H34ClN7O4
Mol. Mass.592.088
SMILESCC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)CC1 |(-1.39,-7.53,;-2.48,-6.44,;-3.97,-6.84,;-5.06,-5.75,;-4.66,-4.26,;-5.75,-3.17,;-5.35,-1.69,;-3.89,-1.21,;-3.89,.33,;-2.55,1.1,;-1.22,.33,;.11,1.1,;1.58,.62,;2.48,1.87,;4.02,1.87,;1.58,3.12,;.81,4.45,;2.91,3.89,;4.38,3.41,;5.28,4.66,;6.82,4.66,;7.59,5.99,;7.59,7.53,;6.26,6.76,;9.13,5.99,;9.9,7.32,;9.9,4.66,;4.38,5.9,;2.91,5.43,;.11,2.64,;-1.22,3.41,;-1.22,4.95,;-2.55,2.64,;-5.35,.81,;-5.98,2.21,;-7.51,2.37,;-8.41,1.13,;-9.9,1.53,;-7.79,-.28,;-6.26,-.44,;-3.17,-3.86,;-2.08,-4.95,)|
Structure
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