| Reaction Details |
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 | Report a problem with these data |
| Target | Protein disulfide-isomerase |
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| Ligand | BDBM104038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDI Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | 1.7e+3± 4e+2 nM |
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| Comments | extracted |
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| Citation |  Ge, J; Zhang, CJ; Li, L; Chong, LM; Wu, X; Hao, P; Sze, SK; Yao, SQ Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS Chem Biol8:2577-85 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein disulfide-isomerase |
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| Name: | Protein disulfide-isomerase |
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| Synonyms: | Cellular thyroid hormone-binding protein | ERBA2L | P4HB | PDI | PDIA1 | PDIA1_HUMAN | PO4DB | Protein Disulfide-Isomerase (PDI) |
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| Type: | Protein |
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| Mol. Mass.: | 57084.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07237 |
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| Residue: | 508 |
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| Sequence: | MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALA
PEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGR
EADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAID
DIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEF
TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR
ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL
PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI
VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGD
DDDLEDLEEAEEPDMEEDDDQKAVKDEL
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| BDBM104038 |
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| n/a |
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| Name | BDBM104038 |
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| Synonyms: | PDI inhibitor P1 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35N3O7S |
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| Mol. Mass. | 569.669 |
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| SMILES | CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(OS(=O)(=O)C=C)cc1)C(=O)NCCC#C |r| |
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| Structure | 
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