| Reaction Details |
|---|
 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
|---|
| Ligand | BDBM311206 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AAK1 Kinase Assay |
|---|
| IC50 | 0.380±n/a nM |
|---|
| Citation |  Luo, G Biaryl kinase inhibitors US Patent US10351563 Publication Date 7/16/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| AP2-associated protein kinase 1 |
|---|
| Name: | AP2-associated protein kinase 1 |
|---|
| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 103884.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774569 |
|---|
| Residue: | 961 |
|---|
| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
|
|
|
|---|
| BDBM311206 |
|---|
| n/a |
|---|
| Name | BDBM311206 |
|---|
| Synonyms: | (S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine | US10155760, Example 50 | US10351563, Example 50 | US10544120, Example 50 | US10723734, Example 50 | US10981910, Example 50 | US9902722, Example 50 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H26F2N2O |
|---|
| Mol. Mass. | 348.43 |
|---|
| SMILES | CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(C)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
