| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
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| Ligand | BDBM104489 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| IC50 | 82.8±0.0 nM |
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| Citation |  Liu, S; Guo, C SGLT-2 inhibitors, methods of making them, and uses thereof US Patent US8575114 Publication Date 11/5/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 2 |
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| Name: | Sodium/glucose cotransporter 2 |
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| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
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| Type: | Protein |
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| Mol. Mass.: | 72902.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31639 |
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| Residue: | 672 |
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| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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| BDBM104489 |
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| n/a |
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| Name | BDBM104489 |
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| Synonyms: | US8575114, I-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20ClN3O6 |
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| Mol. Mass. | 421.832 |
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| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cn2nc3ccccn3c2=O)c1 |r| |
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| Structure | 
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