Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM104538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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IC50 | 35±0.0 nM |
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Citation | Bartolozzi, A; Bosanac, T; Chen, Z; De Lombaert, S; Dines, JA; Huber, JD; Liu, WW; Loke, PL; Morwick, TM; Olague, A; Riether, D; Tye, H; Wu, L; Zindell, RM Oxadiazole inhibitors of leukotriene production US Patent US8575201 Publication Date 11/5/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM104538 |
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n/a |
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Name | BDBM104538 |
Synonyms: | US8575201, 29 |
Type | Small organic molecule |
Emp. Form. | C21H22N8O2 |
Mol. Mass. | 418.4518 |
SMILES | CC(CO)n1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1 |
Structure |
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