| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Ligand | BDBM104978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 9.79±1.93 nM |
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| Citation |  Runyon, SP; Rogawski, MA; Cook, E; Kepler, J; Navarro, H; Kaminski, R; Orr, M Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties US Patent US8575375 Publication Date 11/5/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Name: | Gamma-aminobutyric acid (GABA) B receptor 1 |
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| Synonyms: | GABA-B receptor 1 | GABA-B-R1 | Gamma-aminobutyric acid type B receptor subunit 1 (GABA) | Gb1 | gamma-Aminobutyric Acid Type B Receptor Subunit 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 108221.06 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q6MFX8 |
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| Residue: | 960 |
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| Sequence: | MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA
LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG
WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII
LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF
EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI
IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG
HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL
NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ
LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL
GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF
VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD
VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLL
LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAI
VFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKI
IAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
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| BDBM104978 |
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| n/a |
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| Name | BDBM104978 |
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| Synonyms: | US8575375, C-8 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H40N2O3 |
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| Mol. Mass. | 440.6181 |
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| SMILES | CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)C(CC[C@@H]2[N+]([O-])=O)C2CC[C@H]3C[C@](C)(O)CCC3C12 |r| |
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| Structure | 
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