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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 3-phosphoinositide-dependent protein kinase 1 | ||
| Ligand | BDBM105273 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| IC50 | 2±0.0 nM | ||
| Citation |  Engelhardt, H; Kofink, C; McConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 3-phosphoinositide-dependent protein kinase 1 | |||
| Name: | 3-phosphoinositide-dependent protein kinase 1 | ||
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 63157.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O15530 | ||
| Residue: | 556 | ||
| Sequence: |
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| BDBM105273 | |||
| n/a | |||
| Name | BDBM105273 | ||
| Synonyms: | US8575203, I-40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H33F2N7O3 | ||
| Mol. Mass. | 613.657 | ||
| SMILES | Fc1ccc(Cn2cncc(C(=O)NCC#Cc3ccc4ncc(N[C@H]5CC[C@@H](CC5)N5CCOCC5)nc4c3)c2=O)cc1F |r,wU:25.24,wD:28.31,(8.67,-.39,;7.34,.38,;7.34,1.92,;6,2.69,;4.67,1.92,;3.33,2.69,;3.33,4.23,;4.67,5,;4.67,6.54,;3.33,7.31,;2,6.54,;.67,7.31,;.67,8.85,;-.67,6.54,;-.67,5,;-2,4.23,;-3.33,3.46,;-4.67,2.69,;-6,3.46,;-7.34,2.69,;-7.34,1.15,;-8.67,.38,;-8.67,-1.16,;-7.34,-1.93,;-7.34,-3.47,;-6,-4.24,;-4.67,-3.47,;-3.33,-4.24,;-3.33,-5.78,;-4.67,-6.55,;-6,-5.78,;-2,-6.55,;-2,-8.09,;-.67,-8.85,;.67,-8.09,;.67,-6.55,;-.67,-5.78,;-6,-1.16,;-6,.38,;-4.67,1.15,;2,5,;.67,4.23,;4.67,.38,;6,-.39,;6,-1.93,)| | ||
| Structure | 
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