Reaction Details | |||
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Target | 3-phosphoinositide-dependent protein kinase 1 | ||
Ligand | BDBM105294 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
IC50 | 2±0.0 nM | ||
Citation | Engelhardt, H; Kofink, C; McConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013 | ||
More Info.: | Get all data from this article, Assay Method | ||
3-phosphoinositide-dependent protein kinase 1 | |||
Name: | 3-phosphoinositide-dependent protein kinase 1 | ||
Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 63157.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O15530 | ||
Residue: | 556 | ||
Sequence: |
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BDBM105294 | |||
n/a | |||
Name | BDBM105294 | ||
Synonyms: | US8575203, I-61 | ||
Type | Small organic molecule | ||
Emp. Form. | C39H44FN7O3 | ||
Mol. Mass. | 677.8102 | ||
SMILES | OC[C@H](c1cccc(F)c1)n1cccc(C(=O)NCC#Cc2ccc3ncc(N[C@H]4CC[C@@H](CC4)N4CCN(CC5CC5)CC4)nc3c2)c1=O |r,wU:2.10,29.29,wD:32.36,(2,1.54,;3.33,.77,;4.67,1.54,;6,.77,;7.34,1.54,;8.67,.77,;8.67,-.77,;7.34,-1.54,;7.34,-3.08,;6,-.77,;4.67,3.08,;6,3.85,;6,5.39,;4.67,6.16,;3.33,5.39,;2,6.16,;2,7.7,;.67,5.39,;-.67,6.16,;-2,5.39,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-7.34,2.31,;-8.67,1.54,;-8.67,,;-7.34,-.77,;-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-5.39,;-6,-4.62,;-2,-5.39,;-2,-6.93,;-.67,-7.7,;.67,-6.93,;2,-7.7,;3.33,-6.93,;4.87,-6.93,;4.1,-5.6,;.67,-5.39,;-.67,-4.62,;-6,,;-6,1.54,;-4.67,2.31,;3.33,3.85,;2,3.08,)| | ||
Structure |