Ki Summary

Reaction Details

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Target

3-phosphoinositide-dependent protein kinase 1

Ligand

BDBM105294

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

IC50

2±0.0 nM

Citation

Engelhardt, H; Kofink, C; McConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013

More Info.:

Get all data from this article, Assay Method

3-phosphoinositide-dependent protein kinase 1

Name:

3-phosphoinositide-dependent protein kinase 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

63157.65

Organism:

Homo sapiens (Human)

Description:

O15530

Residue:

556

Sequence:

MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ

BDBM105294

n/a

Name

BDBM105294

Synonyms:

US8575203, I-61

Type

Small organic molecule

Emp. Form.

C39H44FN7O3

Mol. Mass.

677.8102

SMILES

OC[C@H](c1cccc(F)c1)n1cccc(C(=O)NCC#Cc2ccc3ncc(N[C@H]4CC[C@@H](CC4)N4CCN(CC5CC5)CC4)nc3c2)c1=O |r,wU:2.10,29.29,wD:32.36,(2,1.54,;3.33,.77,;4.67,1.54,;6,.77,;7.34,1.54,;8.67,.77,;8.67,-.77,;7.34,-1.54,;7.34,-3.08,;6,-.77,;4.67,3.08,;6,3.85,;6,5.39,;4.67,6.16,;3.33,5.39,;2,6.16,;2,7.7,;.67,5.39,;-.67,6.16,;-2,5.39,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-7.34,2.31,;-8.67,1.54,;-8.67,,;-7.34,-.77,;-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-5.39,;-6,-4.62,;-2,-5.39,;-2,-6.93,;-.67,-7.7,;.67,-6.93,;2,-7.7,;3.33,-6.93,;4.87,-6.93,;4.1,-5.6,;.67,-5.39,;-.67,-4.62,;-6,,;-6,1.54,;-4.67,2.31,;3.33,3.85,;2,3.08,)|

Structure