Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-3

Ligand

BDBM106900

Substrate/Competitor

n/a

Meas. Tech.

ATP Depletion Assay

7.5±0

IC50

1±n/a nM

Citation

Burger, MT; Han, W; Lan, J; Nishiguchi, G Kinase inhibitors and methods of their use US Patent US8592455 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Serine/threonine-protein kinase pim-3

Name:

Serine/threonine-protein kinase pim-3

Synonyms:

PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)

Type:

Protein

Mol. Mass.:

35888.19

Organism:

Homo sapiens (Human)

Description:

Q86V86

Residue:

326

Sequence:

MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL

BDBM106900

n/a

Name

BDBM106900

Synonyms:

US8592455, 100

Type

Small organic molecule

Emp. Form.

C23H22F3N5O

Mol. Mass.

441.4489

SMILES

N[C@H]1CCC[C@H](C1)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F |r,wD:5.7,1.0,(-1.33,2.69,;-2.67,1.93,;-4,2.69,;-5.33,1.93,;-5.33,.38,;-4,-.38,;-2.67,.38,;-4,-1.93,;-5.33,-2.69,;-5.33,-4.23,;-4,-5,;-2.67,-4.23,;-2.67,-2.69,;-1.33,-1.93,;,-2.69,;,-4.23,;1.33,-1.93,;1.33,-.38,;2.67,.38,;4,-.38,;5.33,.38,;4,-1.93,;2.67,-2.69,;2.67,-4.23,;2.67,1.93,;4,2.69,;5.33,1.93,;4,4.23,;2.67,5,;1.33,4.23,;1.33,2.69,;,1.93,)|

Structure