Ki Summary

Reaction Details

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Target

Acetyl-coenzyme A transporter 1

Ligand

BDBM107390

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±0

IC50

1.6±0.0 nM

Citation

Maekawa, T; Igawa, H Fused ring compound and use thereof US Patent US8592431 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Acetyl-coenzyme A transporter 1

Name:

Acetyl-coenzyme A transporter 1

Synonyms:

ACATN | ACATN_HUMAN | AT1 | Acetyl-coenzyme A transporter 1 (AT1) | SLC33A1

Type:

Enzyme

Mol. Mass.:

60911.27

Organism:

Homo sapiens (Human)

Description:

O00400

Residue:

549

Sequence:

MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN

BDBM107390

n/a

Name

BDBM107390

Synonyms:

US8592431, 216

Type

Small organic molecule

Emp. Form.

C33H37N7O5

Mol. Mass.

611.6908

SMILES

CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OC\C(C)=N\OC)c2ncnn12 |r,wU:27.29,wD:30.36,(-8,1.67,;-6.67,2.44,;-5.33,1.67,;-4,2.44,;-2.67,1.67,;-2.67,.13,;-4,-.64,;-4,-2.18,;-5.33,-2.95,;-6.67,-2.18,;-6.67,-.64,;-5.33,.13,;-8,-2.95,;-9.34,-2.18,;-10.67,-2.95,;-10.67,-4.49,;-9.34,-5.26,;-8,-4.49,;-6.67,-5.26,;-6.67,-6.8,;-5.2,-7.27,;-4.43,-8.6,;-4.3,-6.03,;-5.2,-4.78,;-1.33,2.44,;,1.67,;-1.33,3.98,;,4.75,;,6.29,;1.33,7.06,;2.67,6.29,;2.67,4.75,;1.33,3.98,;4,7.06,;5.33,6.29,;6.67,7.06,;6.67,8.6,;8,6.29,;9.34,7.06,;10.67,6.29,;-2.67,4.75,;-2.99,6.26,;-4.52,6.42,;-5.15,5.02,;-4,3.98,)|

Structure