Ki Summary

Reaction Details

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Target

Acetyl-coenzyme A transporter 1

Ligand

BDBM107404

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±0

IC50

1.7±0.0 nM

Citation

Maekawa, T; Igawa, H Fused ring compound and use thereof US Patent US8592431 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Acetyl-coenzyme A transporter 1

Name:

Acetyl-coenzyme A transporter 1

Synonyms:

ACATN | ACATN_HUMAN | AT1 | Acetyl-coenzyme A transporter 1 (AT1) | SLC33A1

Type:

Enzyme

Mol. Mass.:

60911.27

Organism:

Homo sapiens (Human)

Description:

O00400

Residue:

549

Sequence:

MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN

BDBM107404

n/a

Name

BDBM107404

Synonyms:

US8592431, 273

Type

Small organic molecule

Emp. Form.

C35H34N6O5

Mol. Mass.

618.6817

SMILES

CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)Oc2ccc(O)cc2)c2ncnn12 |r,wU:27.29,wD:30.36,(-7.57,2.37,;-6,3.21,;-4.67,2.44,;-3.33,3.21,;-2,2.44,;-2,.9,;-3.33,.13,;-3.33,-1.41,;-4.67,-2.18,;-6,-1.41,;-6,.13,;-4.67,.9,;-7.34,-2.18,;-8.67,-1.41,;-10,-2.18,;-10,-3.72,;-8.67,-4.49,;-7.34,-3.72,;-6,-4.49,;-6,-6.03,;-4.54,-6.5,;-3.77,-7.84,;-3.63,-5.26,;-4.54,-4.01,;-.67,3.21,;.67,2.44,;-.67,4.75,;.67,5.52,;.67,7.07,;2,7.84,;3.33,7.07,;3.33,5.52,;2,4.75,;4.67,7.84,;6,7.07,;6,5.52,;7.34,4.75,;8.67,5.52,;10,4.75,;8.67,7.07,;7.34,7.84,;-2,5.52,;-2.32,7.03,;-3.85,7.19,;-4.48,5.79,;-3.33,4.75,)|

Structure