| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [1148-1435] |
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| Ligand | BDBM50123470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV-1 Integrase Assay |
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| IC50 | 3.7e+2±n/a nM |
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| Citation |  Bhatt, H; Patel, P; Pannecouque, C Discovery of HIV-1 integrase inhibitors: pharmacophore mapping, virtual screening, molecular docking, synthesis, and biological evaluation. Chem Biol Drug Des83:154-66 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [1148-1435] |
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| Name: | Gag-Pol polyprotein [1148-1435] |
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| Synonyms: | HIV-1 Integrase | POL_HV1H2 | gag-pol |
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| Type: | Enzyme |
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| Mol. Mass.: | 32171.42 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | The sequence encoding the 288-amino-acid wild-type full-length integrase was cloned with an N-terminal 6His tag, and expressed in E. coli. |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTGATVRAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50123470 |
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| n/a |
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| Name | BDBM50123470 |
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| Synonyms: | (3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methanone | (3-benzylphenyl)(8-hydroxyquinolin-7-yl)methanone | 7-(3-benzylbenzoyl)quinolin-8-ol (Compound 7) | CHEMBL35842 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17NO2 |
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| Mol. Mass. | 339.3866 |
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| SMILES | Oc1c(ccc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1 |
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| Structure | 
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