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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM107797 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 1.00±0.0 nM | ||
| Citation |  Helal, CJ; Chappie, TA; Humphrey, JM; Verhoest, PR; Yang, E Imidazo[5,1-f][1,2,4]triazines for the treatment of neurological disorders US Patent US8598155 Publication Date 12/3/2013 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM107797 | |||
| n/a | |||
| Name | BDBM107797 | ||
| Synonyms: | US8598155, 34 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H17ClFN7 | ||
| Mol. Mass. | 397.837 | ||
| SMILES | Cc1nc(-c2cnn(C)c2-c2ccc(Cl)cc2F)c2c(ncnn12)N1CCC1 |(-.46,-3.97,;-1.23,-2.64,;-.32,-1.39,;-1.23,-.15,;-.46,1.19,;-1.36,2.43,;-.46,3.68,;1.01,3.2,;2.34,3.97,;1.01,1.66,;2.09,.57,;1.7,-.91,;2.78,-2,;4.27,-1.6,;5.36,-2.69,;4.67,-.12,;3.58,.97,;3.98,2.46,;-2.69,-.62,;-4.03,.15,;-5.36,-.62,;-5.36,-2.16,;-4.03,-2.93,;-2.69,-2.16,;-4.03,1.69,;-2.94,2.78,;-4.03,3.86,;-5.12,2.78,)| | ||
| Structure | 
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