Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM281763 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.0003±n/a nM | ||
Comments | extracted | ||
Citation | Watterson, SH; Tebben, AJ; Ahmad, S Carbazole and tetrahydrocarbazole compounds useful as inhibitors of BTK US Patent US10023534 Publication Date 7/17/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM281763 | |||
n/a | |||
Name | BDBM281763 | ||
Synonyms: | 9-(2-acryloyl-1,2,3,4- tetrahydroisoquinolin- 5-yl)-8-fluoro-5H- pyrido[4,3-b]indole-6- carboxamide | US10023534, Example 31 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H19FN4O2 | ||
Mol. Mass. | 414.4317 | ||
SMILES | NC(=O)c1cc(F)c(-c2cccc3CN(CCc23)C(=O)C=C)c2c3cnccc3[nH]c12 |(.26,5.77,;-1.07,5,;-2.4,5.77,;-1.07,3.46,;.26,2.69,;.26,1.15,;1.6,.38,;-1.07,.38,;-1.07,-1.16,;-2.4,-1.92,;-2.4,-3.46,;-1.07,-4.23,;.26,-3.46,;1.6,-4.23,;2.93,-3.46,;2.93,-1.92,;1.6,-1.16,;.26,-1.92,;4.26,-4.23,;4.26,-5.77,;5.6,-3.46,;6.93,-4.23,;-2.4,1.15,;-3.87,.68,;-4.49,-.73,;-6.03,-.89,;-6.93,.36,;-6.31,1.76,;-4.77,1.92,;-3.87,3.17,;-2.4,2.69,)| | ||
Structure |